• Dihexa - Zion Pharma



Dihexa – pure powder

SKU: dihexa-powder



OTHER NAMES: N-(1-Oxohexyl)-l-tyrosyl-N-(6-amino-6-oxohexyl)-l-isoleucinamide

CAS NUMBER: 1401708-83-5



MOLAR MASS: 504.672 g·mol−1


QUANTITY PER PACK: 0.250 to 0.500 gram



STORAGE: Store in a cool and dry place. Keep away from direct sunlight and heat.

WARNING: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.

DISCLAIMER: Always consult with a qualified health physician before taking any new dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any diseases.

SCOOPS: This product includes a measuring scoop (yellow) = 5 mg (approximately – big.).

The product is not intended for human use. For laboratory use only.

Dihexa, or N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, first known PNB-0408, is a novel nootropic compound and experimental drug that has been developed for possible treatment of trauma-based brain disorders and neurodegenerative conditions (i.e., Alzheimer’s, Parkinson’s) that would compensate for arisen cognitive deficits through increased synaptogenesis.

It is an oligopeptide (small peptide) drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF), a neurotrophic agent in many brain regions, and potentiates its activity at its receptor, c-Met.

Studies in rats have shown its enormous potency as a neurotrophic agent, being up to ten million times stronger than BDNF (brain-derived neurotrophic factor). Furthermore, dihexa possess neuroprotective properties, as other animal studies have demonstrated anti-inflammatory and anti-apoptotic effects of the drug.

Since this substance hasn’t been tested in humans, caution is advised when handling this extremely potent nootropic.

Benefits of taking dihexa

  • increased mental endurance;
  • enhanced perception and awareness of surroundings;
  • improved short- and long-term memory;
  • amelioration of depressive symptoms;
  • increased verbal fluency;
  • boost in creativity and problem-solving skills;
  • heightened social intuition and enhanced social skills;
  • increased processing speed and improved reaction time;
  • better focus;
  • increased learning capacity;
  • lessened anxiety.

Side effects

Due to extreme neuroplasticity potential enabled by dihexa, some of its benefits and adverse effects are likely to depend on the user’s lifestyle and circumstances over the course of supplementation.

  • headaches;
  • nausea;
  • dizziness;
  • insomnia;
  • water retention;
  • attention deficit from prolonged use;
  • increased severity or development of autistic-like symptoms;
  • strengthening of habits, including bad ones;
  • possible withdrawal symptoms (jitteriness, irritability).

There are concerns that while dihexa itself might not be carcinogenic, it might accelerate the growth of pre-existing cancer.


Dihexa can be taken orally, via nasal spray or subcutaneous injection.

Oral ingestion is the most popular route of administration for dihexa, with the average ranges of dosage between 8 and 45 milligrams per day in a single dose, with or without food.