• GTS-21 Zion Pharma

GTS-21 dihydrochloride


GTS-21 dihydrochloride (DMXBA) – powder

SKU: gts-21-powder

ACTIVE INGREDIENT: GTS-21 dihydrochloride


OTHER NAMES: GTS-21 Dihydrochloride (DMBX-A), E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3ʹ-bipyridine, DMBX-A, α7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21

CAS NUMBER: 156223-05-1


FORMULA: C19H20N2O2 · 2HCl

MOLAR MASS: 308.381 g·mol−1


QUANTITY PER PACK: 1 to 2 grams



STORAGE: Store in a cool and dry place. Keep away from direct sunlight and heat.

WARNING: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.

DISCLAIMER: Always consult with a qualified health physician before taking any new dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any diseases.

SCOOPS: This product includes a measuring scoop

The product is not intended for human use. For laboratory use only.

GTS-21, also known as DMXBA or DMBX-anabaseine, is an experimental drug that has been studied for its therapeutical potential in the treatment of neurodegenerative diseases and psychiatric disorders.

It is a partial agonist of one of the acetylcholine receptor subtypes, namely the α7 nicotinic receptor, activation of which has been linked to neuroprotective effects and cognitive function improvement.

GTS-21 has been shown to have anti-inflammatory, neuroprotective effects in various animal models of neurodegenerative disorders such as Alzheimer’s, Parkinson’s and multiple sclerosis, an improvement in cognitive function has also been observed.

Currently, it is also being investigated for the treatment of schizophrenia and nicotine addiction. In a study on patients with schizophrenia, the drug has improved several measures of cognitive function, including attention and working memory, without causing significant side effects.

Another study results suggest that GTS-21 can act as a cognitive enhancer for healthy people as well, improving attention and memory performance, and augmenting the effects of caffeine on cognition.  

Benefits of taking GTS-21

  • improved memory;
  • boost in attention and alertness;
  • enhanced perception;
  • anti-inflammatory and neuroprotective effects;
  • enhanced mood;
  • caffeine potentiation;
  • possible smoking cessation aid;
  • increased processing speed.


Side effects 

GTS-21 seems to be well tolerated up to 450 mg/day, however, some adverse effects might occur.

  • stomach irritation;
  • elevated liver enzymes;
  • postural hypotension;
  • vasoconstriction.


GTS-21 is taken orally, with 75-150 mg doses up to three times a day.

Due to its irritant effect on mucous membranes, it is advised not to swallow the powder, but use capsules instead. Also, it is better not to let the powder come in contact with the skin, as it can dye it yellow.