• Methylene blue - Zion Pharma

Methylene blue – nootropic powder


Methylene blue – powder almost 100% purity.

Methylene Blue, a synthetic compound, is used as a nootropic to enhance memory, mood, and longevity.

SKU: methylene-blue-powder

ACTIVE INGREDIENT: Methylene blue >99%


OTHER NAMES: Methylthioninium chloride; Urelene blue; Provayblue; Proveblue; Phenothiazin-5-ium; 3,7-bis(dimethylamino)-, chloride

CAS NUMBER: 61-73-4

ATC CODE: V03AB17; V04CG05;


MOLAR MASS: 319.85 g·mol−1


QUANTITY PER PACK: 1 to 5 grams


SUGGESTED USE: From 0.5 mg to 4 mg per 1 kg of body weight per day.

STORAGE: Store in a cool and dry place. Keep away from direct sunlight and heat.

WARNING: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.

DISCLAIMER: Always consult with a qualified health physician before taking any new dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any diseases.

SCOOPS: This product includes a measuring scoop (blue) = 50 mg (approximately).

NOTE: methyl blue is a colorant. It intensely colors blue. It can also stain urine blue!

The product is not intended for human use. For laboratory use only.

Methylene Blue was synthesized a blue dye for textiles in the late 1800’s. Soon, it became the first synthetic drug to be used in humans – it was used for the treatment of malaria.

Methylene Blue is currently being studied as potential therapy for mild cognitive impairment, Alzheimer’s, Parkinson’s, and other neurodegenerative disorders that share a common problem with mitochondrial function. As a nootropic, methylene blue readily crosses the blood-brain barrier. It improves mitochondrial efficiency and respiration, acts as an antioxidant, and increases brain cell lifespan, which results in improved memory and mood. Research shows that methylene blue is an acetylcholinesterase inhibitor with a preference for muscarinic acetylcholine receptors, which means that it prevents the breakdown of acetylcholine, and making it more available in the brain. Methylene blue may also be effective for bipolar disorder symptoms if combined with lamotrigine (a mood stabilizer).

It is important to note that methylene blue is a monoamine oxidase inhibitor (MAOI) with preference for MAO-A, however in larger doses, it inhibits MAO-B as well. This effect becomes significant at about 2 mg/kg.

Benefits of taking methylene blue

  • improved short-term and long-term memory;
  • enhanced mood and antidepressant effect;
  • boost in energy;
  • rejuvenation;
  • increased comprehension of complex material;
  • enhanced learning;
  • positive perception of events;
  • anxiolytic effect;
  • improved sleep;
  • increased self-confidence.


  • other MAOIs;
  • SSRI / SNRI;
  • tricyclic antidepressants;
  • stimulants.

Side effects

Side effects of methylene blue are rare with doses under 2 mg/kg.

  • blue urine;
  • stomach pain;
  • chest pain;
  • dizziness;
  • sweating;
  • high blood pressure;
  • confusion.


Recommended safe doses based on clinical studies range from 0.5 – 4 mg/kg. With the half-life of methylene blue at about 5 hours, it should be taken twice a day.

It is safer to start with 0.5 mg/kg and observe the results.