• Tadalafil pure powder

Tadalafil pure powder


Improvement of cognitive dysfunction by a phosphodiesterase type 5 inhibitor – Tadalafil.

SKU: tadalafil-powder



OTHER NAMES: Cialis; IC 351; IC-351; IC351; Pyrazino(1′,2′:1,6)pyrido(3,4-b)indole-1,4-dione, 6-(1,3- benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)-

CAS NUMBER: 171596-29-5



MOLAR MASS: 389.411 g·mol−1


QUANTITY PER PACK: 0.5 to 2 grams



STORAGE: Store in a cool and dry place. Keep away from direct sunlight and heat.

WARNING: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.

DISCLAIMER: Always consult with a qualified health physician before taking any new dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any diseases.

SCOOPS: This product includes a measuring scoop (yellow) = 2/10 mg (approximately).

The product is not intended for human use. For laboratory use only.

Tadalafil is a type-5 phosphodiesterase enzyme inhibitor with long half-life used to treat erectile dysfunction. Phosphodiesterase (PDE) 5 inhibitors regulate signaling pathways by elevating cyclic guanosine monophosphate (cGMP) levels. They may enhance cerebral blood flow (CBF) through the vasoactive effects of cGMP, whereas a decline in CBF has been long implied in cognitive dysfunction. Since vascular problems are the most common etiology of ED, it is associated with diminished cognitive performance, especially in the aspects of attention, executive functioning, and processing speed. As more and more patients were put on daily low-dose tadalafil, it became apparent that it might enhance cognition. Cerebral blood flow increase aside, some other mechanisms have been proposed to explain this finding. Some reports propose that PDE 5 inhibitors may exert their pro-cognitive action through emotional arousal, while other point it out that enhanced second messenger signaling also results in the facilitation of long-term potentiation (LTP) processes.

Animal studies have shown that L-NAME (NG-nitro-L-arginine methyl ester) aggravated scopolamine- and diabetes-induced learning and memory deficit was significantly reversed by tadalafil.

Some studies have shown significant increases in testosterone and cortisol when tadalafil is taken pre-workout, which decreases the period of time needed to reach maximum power.

Anecdotal evidence suggests that tadalafil might lift brain fog, alleviate the symptoms of depression, anhedonia and derealization.

Benefits of taking tadalafil

  • alleviation of the symptoms of ED (erectile dysfunction);
  • increased cerebral blood flow;
  • enhanced working memory;
  • improved mental clarity;
  • boost in learning capacity;
  • increased body awareness;
  • protection from oxidative stress;
  • improved executive function;
  • enhanced mood;
  • boost in power when taken pre-workout;
  • potential aid in the treatment of depression.

Side effects:

The below side effects are unlikely to be experienced with low-dose tadalafil.

  • headache;
  • nausea (avoiding spicy food might help);
  • indigestion;
  • facial flushes and hot flushes;
  • stuffy nose;
  • muscle aches.


Typical pro-cognitive dose of tadalafil is 5 mg, taken once a day.