• Theacrine - Zion Pharma

Theacrine capsules 100 mg


Theacrine capsules 100 mg

Theacrine is a supplement that can increase energy, sharpen mental focus, and prolong endurance. It is sometimes used as a nootropic supplement for its cognitive enhancement benefits.

Theacrine is produced from caffeine in certain plants; mainly teas and coffees. Recent research has shown theacrine as a tolerance-free caffeine replacement.

SKU: theacrine-capsules


ADDITIONAL INGREDIENTS: gelatin capsules, microcrystalline cellulose

OTHER NAMES: 1,3,7,9-tetramethyluric acid, Temurin; Temorine; Tetramethyluric acid; Tetramethyl uric acid; TeaCrine

CAS NUMBER: 2309-49-1



ITEM TYPE: Capsules

QUANTITY PER PACK: 30 capsules to 100 capsules



STORAGE: Store in a cool and dry place. Keep away from direct sunlight and heat.

WARNING: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.

DISCLAIMER: Always consult with a qualified health physician before taking any new dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any diseases.

The product is not intended for human use. For laboratory use only.

Teacrine – an antidepressant from tea

Theacrine is a natural replacement for caffeine. Indicated especially for people who, for various reasons, cannot tolerate caffeine. However, they need a legitimate boost and “turn up the heat” on their ability to concentrate and focus on the task at hand. Human studies show that theacrine can brighten the mind, increase energy and boost mood and motivation. In this way, it indirectly has a nootropic effect.

What is theacrine?

Theacrine (1,3,7,9-Tetramethyluric acid; Temurine; Temorine; Tetramethyluric acid; Tetramethyluric acid;) is a purine alkaloid found in the cupuacu fruit (Theobroma grandiflorum) and the kucha plant (Camellia assamica var. kucha) and Pu’er tea (considered red tea in our country, but black tea in China).

Kucha is a plant close to tea and grows only in the forests of Yunnan province in China at altitudes above 1,000 meters above sea level. It is used to make Chinese kucha tea. It also contains caffeine and theobromine.

The chemical structure of theacrine is similar to caffeine, and it probably activates similar receptors in cells as caffeine.

How does theacrine work?

Knowledge of how theacrine works comes mainly from animal studies. Theacrine binds to adenosine receptors (ADORA1, ADORA2A) in mice and rats and acts differently depending on the dose.

A high dose, 48 mg/kg (in rats) blocks adenosine receptors. This mechanism counteracts adenosine-induced drowsiness. Caffeine has a similar effect. In contrast, smaller doses, 3 mg/kg (this time in mice) show the opposite effect, increasing adenosine levels in the hippocampus in the brain and counteracting the stimulatory property of caffeine. High doses of theacrine also activate dopamine D1 and D2 receptors (in rats). Activation of these receptors is responsible for motivation and wakefulness.

Differences between theacrine and caffeine:

  • Has a longer half-life;
  • has no effect on blood pressure;
  • does not disrupt sleep like caffeine;
  • theacrine and caffeine are more effective when administered together – they work in synergy;
  • caffeine increases the bioavailability and positive effects of theacrine;
  • can increase energy;
  • improves concentration and motivation;
  • can improve mood;
  • may lower bad cholesterol to a small extent.

Minuses: no “hard” evidence of the above-mentioned effects.

Theacrine is a brain/central nervous system stimulant. It has become popular among athletes as a pre-workout and fat burner. Athletes who use it claim that it provides a long-lasting energy boost without negative side effects such as anxiety or insomnia. This gives it an advantage over caffeine.


In one human study, it was proven that a single dose of 200 mg of teacrine caused a subjective increase in energy, focus, concentration, desire to exercise, motivation to train and increased libido.

Another study reported increased subjective feelings of attentiveness, alertness and focus when taking a supplement containing both theacrine and caffeine.

Theacrine significantly increased physical activity in rats, and it is suggested that this effect is mediated by both the adenosine and dopamine systems.

As you can see, there hasn’t been much research to date. However, it can be suggested that theacrine does indeed increase energy levels and improve concentration and motivation to perform.


High levels of dopamine result in feelings of energy, improved mood and pleasure.

In rats, high doses of theacrine activate the dopamine receptors DRD1 and DRD2. Theacrine increases activity in the region of the caudate nucleus (nucleus accumbens) in the brain, which is associated with pleasure and the feeling of being rewarded.

Using both teacrine and caffeine at the same time has had a beneficial effect on many subjective feelings of energy and mood compared to caffeine alone. It also reduces feelings of lethargy and drowsiness.

In mice, theacrine reduces depression or depression-like conditions.

Lowers cholesterol levels

Theacrine may act, like the polyphenols found in tea, to inhibit the absorption of cholesterol from the diet and lower the level of cholesterol found in the blood.

A study of 60 healthy people showed that supplementation with theacrine in high doses can slightly lower LDL cholesterol and total cholesterol.


A low dose of theacrine shortened wakefulness and prolonged sleep time in mice. It also reduces caffeine-induced insomnia.

In addition, teacrine markedly increased adenosine levels in the brain (hippocampus) of rats, which has a facilitating effect.

These results show that teacrine can probably regulate the adenosine system when used in low doses, and thus improve and prolong sleep duration. It is possible that it has the same or similar effect in humans.

Theacrine vs. caffeine

Caffeine stimulates quickly. The stimulation lasts a few hours and there is a downhill slide, a loss of strength and energy. You have to drink another cup of coffee – a bigger one. There is an increase in tolerance. Of course, not in one day. Coffee drinkers know that with frequent use, the need for caffeine increases and its effectiveness decreases.

Theacrine probably does not cause an increase in tolerance. At least so far, it has not been observed to a greater degree. The same dose can be used for many weeks without a decrease in stimulant effect.

Teacrine does not cause an increase in blood pressure, anxiety or insomnia. In this it has a clear advantage over caffeine.


There are no official indications on the dosage of theacrine. In Poland, it is not approved as a drug, dietary supplement or foodstuff. This means that it can be offered (because it is also not banned) as a chemical reagent or other substance. The result is that teacrine dosage cannot be given either. Everything is unofficial.

Manufacturers of nutrients and supplements from abroad give dosages at their own discretion. They use available studies and user feedback.

It is believed that theacrine works differently at a low dose and differently at a higher dose. Doses up to 50 mg have a more relaxing and sedative-couching effect. In contrast, doses above 50 mg to 300 mg should have a stimulating effect, more similar to coffee.

Kucha tea has lower doses of theacrine and is used traditionally for sedation and relaxation. Extracts and pure theacrine powder can be dosed precisely and higher doses are easier to achieve.

Theacrine is of natural origin and should be quite safe to use. However, it is worth exercising caution as with all drugs. Drugs in the sense of substances we use to improve our own condition.

For example, Kucha tea contains low doses and has been used to induce relaxation.