• Yohimbine 98% - Zion Pharma

Yohimbine HCl 98%


Yohimbine HCl purity above 98%

SKU: yohimbine-hcl-powder



CAS NUMBER: 65-19-0



ITEM TYPE: powder


SERVINGS PER PACK: not specified

SUGGESTED USE: not specified

STORAGE: Store in a cool and dry place. Keep away from direct sunlight and heat.

WARNING: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.

DISCLAIMER: Always consult with a qualified health physician before taking any new dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any diseases.

SCOOPS: This product includes a measuring scoop (red) = 5 mg (approximately).

The product is not intended for human use. For laboratory use only.

Yohimbine is a naturally occurring alkaloid found in the evergreen tree native to western and central Africa Pausinystalia yohimbe and the Rauwolfia serpentina plant. Yohimbine is a stimulatory compound that, unlike classic CNS stimulants, acts primarily on the alpha-2-adrenergic receptors in the body. Yohimbine is best known for its lipolytic effect (ability to increase “fat burning”) and is believed to improve body composition.

It is also worth mentioning that before sildenafil was introduced, yohimbine had been extensively used to improve symptoms of erectile dysfunction (ED) in men. Yohimbine HCl has proven to be safe and particularly effective in combination with L-arginine for the treatment of mild to moderate erectile dysfunction in 40 male patients

Yohimbine blocks alpha-1 and alpha-2 adrenoceptors, increasing adrenaline and dopamine and decreasing serotonin levels. Blocking these receptors leads to an increase in blood pressure, insulin release and decrease in blood sugar levels. As a selective alpha-2-adrenergic antagonist, yohimbine targets and inactivates a class of receptors in the nervous system that is responsive to norepinephrine. It enhances the sympathetic nervous system release of norepinephrine, causing the stimulatory and “hyperadrenergic” effects of yohimbine. Alpha-2 receptors antagonism also inhibits penile smooth muscle contraction and may enhance nitric oxide-mediated smooth muscle relaxation. The combination of the above effects promotes erection and explains the improvement in ED symptoms achieved with supplementing with yohimbine. While norepinephrine normally acts to suppress fat release, inhibition of this action by yohimbine allows more lipolysis (“fat burning”) to occur.

According to three small clinical trials, consuming yohimbine before exercise or during fasting increased fat breakdown. Another study in 20 athletes showed that daily yohimbine supplementation reduced body fat levels from 9.3 to 7.1%.

Interestingly enough, supplementing yohimbine might also be beneficial for mental health and cognition. In a study of 40 patients with social anxiety disorder, yohimbine decreased social anxiety and increased mood. Several other studies (in animals and humans) have found that yohimbine might help fear extinction by increasing norepinephrine.

Raising norepinephrine levels could also improve long-term memory, which has been confirmed by a study on 36 adults supplementing yohimbine.

Some studies suggest that yohimbine might alleviate chronic pain. It may also help with dry mouth by increasing acetylcholine, reduce blood clotting, inflammation and improved kidney function, and might also help with blood sugar control in type 2 diabetes.

Anecdotal evidence suggests that yohimbine might be useful in the treatment of ADHD, particularly the predominantly inattentive subtype.


Benefits of taking yohimbine

  • boost in energy;
  • reduced fatigue;
  • increased endurance;
  • enhanced attention and focus;
  • improved long-term memory;
  • increased social confidence;
  • enhanced mood;
  • alleviation of the symptoms of ED (erectile dysfunction);
  • possible aid in weight loss.


Side effects

Note: yohimbine has been linked to many adverse cardiac events, which is most likely due to individual differences in bioavailability (even up to 1000-fold according to some estimates, as it is a highly sensitive CYP2D6 substrate)

  • high blood pressure;
  • palpitations;
  • anxiety;
  • panic attacks;
  • sleep disturbances;
  • diarrhea.


  • MAOIs;
  • other stimulants;
  • CYP2D6 inhibitors and substrates (bupropion, some SSRIs, SNRIs and TCAs);
  • CYP3A4 inhibitors (grapefruit juice, apigenin).


Due to aforementioned individual differences it is advised to start low: 2,5 mg on empty stomach, preferably 20-30 minutes before breakfast. On consecutive days, dosage can be gradually increased until optimal response is reached. Standard dose is estimated at 0.2 mg / kg, it is also advise not to exceed 30 mg.